This may throw some more light, however it s not clear who the spouse is (with the cert or a trawl through the BMD's)

The 1851 Ruardean entry for Enos 1823 suggests she may be Mary GAGE [GAGG?] 1811 with a daughter Mary Ann 1838

Name: Enos Brain
Year of Registration: 1845
Quarter of Registration: Oct-Nov-Dec
District: Ross
County: Gloucestershire
Volume: 26
Page: 369

Year: 1822
Month: Feb
Day: 13
Parents_Surname: BRAIN
Child_Forenames: Enos
Fathers_Forenames: James
Mothers_Forenames: Sarah
Mothers_Surname:
Residence:
Occupation:
Officiating_Minister: Jn HORLICK
Event: Baptism
Memoranda: Born: 1821/11/08
Notes:
Register_Reference:
Page_Number:
Parish_Chapel: Ruardean Independent